Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• . Three different approaches to such reaction systems are presented herein and discussed in view of their advantages and disadvantages as well as trends for their future development. Keywords: biocatalysis; chemo-enzymatic reaction sequences; continuous flow; coupled reactions; reaction cascades

• waste [16][17]. Therefore such processes are generally expected to have a higher “green index” [18] and E-factor (kilograms of total waste produced per kilogram of product) [19]. One may also consider so-called chemo-enzymatic reaction sequences, that is multistep-reaction systems in which chemical and